Pramiracetam is known under the chemical name, [N-[2-[bis(1-methylethyl)amino]ethyl]-2 oxo-1-pyrrolidineacetamide sulfate]. It is one of the newer nootropics in the racetam chemical class and has a similar method of action to other racetams. It is believed to influence the Glutamate (Cholinergic) and specifically, the ACh (Acetylcholine) receptor sites by improving reuptake and the efficiency of their channels.

Unlike Aniracetam and Noopept, Pramiracetam does not seem to influence the dopaminergic or serotonin (5HT) receptor sites. Instead, Pramiracetam seems to have a high affinity in influencing choline uptake into the hippocampus. Other areas of the cerebral cortex do not seem to be affected by the chemical. Pramiracetam is believed to strictly influence acetylcholine uptake and channel specific nerve impulses in the hippocampus.

Pramiracetam has a very specific method of action in hippocampal Acetylcholine turnover. It may be a common culprit for causing headaches and fatigue because of ACh receptor “burn out“. A common way to avoid this would be to supplement with Alpha GPC n order to increase the level of bioavailable acetylcholine. This is just a theory but studies have shown Pramiracetam to have a specific function on these hippocampal ACh receptors.